Journal article
Multisensory stimulation improves functional recovery and resting-state functional connectivity in the mouse brain after stroke
J Hakon, MJ Quattromani, C Sjölund, G Tomasevic, L Carey, JM Lee, K Ruscher, T Wieloch, AQ Bauer
Neuroimage Clinical | ELSEVIER SCI LTD | Published : 2018
Abstract
Stroke causes direct structural damage to local brain networks and indirect functional damage to distant brain regions. Neuroplasticity after stroke involves molecular changes within perilesional tissue that can be influenced by regions functionally connected to the site of injury. Spontaneous functional recovery can be enhanced by rehabilitative strategies, which provides experience-driven cell signaling in the brain that enhances plasticity. Functional neuroimaging in humans and rodents has shown that spontaneous recovery of sensorimotor function after stroke is associated with changes in resting-state functional connectivity (RS-FC) within and across brain networks. At the molecular level..
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Awarded by National Institutes of Health
Funding Acknowledgements
The authors want to thank Kerstin Beirup for outstanding technical assistance. This work was supported by NIH grant 5K25NS08375404 (AQB), the Swedish Research Council (TW 2011-2652 and 2014-3802), the Hans-Gabriel and Alice Trolle-Wachtmeister Foundation (TW 126360), Alborada Trust (TW), the Strategic Research Area MultiPark (TW 128000), the Pia Stahl Foundation (TW 31434731240), the Royal Physiographic Society of Lund (JH, TW and MJQ 110312), and the STROKE Riksforbundet (MJQ 110316), James S. McDonnell Foundation 21st Century Science Initiative in Cognitive Rehabilitation-Collaborative Award (# 220020413) and NHMRC grants (1022694; 1077898) (LC).